The LOC387715 Polymorphism, Inflammatory Markers, Smoking, and Age-Related Macular Degeneration
نویسندگان
چکیده
منابع مشابه
Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.
We used iterative association mapping to identify a susceptibility gene for age-related macular degeneration (AMD) on chromosome 10q26, which is one of the most consistently implicated linkage regions for this disorder. We employed linkage analysis methods, followed by family-based and case-control association analyses, using two independent data sets. To identify statistically the most likely ...
متن کاملNeovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism.
OBJECTIVE To compare phenotypes of 2 age-related macular degeneration (AMD) susceptibility genes: LOC387715 and complement factor H (CFH). METHODS Phenotypes of 755 AMD cases were characterized. The number of LOC387715 (T allele at rs10490924, or A69S) and CFH (T1277C at rs1061170, or Y402H) risk alleles were determined in each case. Individuals were divided into 5 groups by genotype: group 1...
متن کاملNeovascular Age-Related Macular Degeneration Risk Based on CFH, LOC387715/HTRA1, and Smoking
BACKGROUND Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smokin...
متن کاملSmoking and age-related macular degeneration.
A recent study demonstrated that a particular genetic susceptibility (LOC387715), combined with smoking, confers a significantly higher risk of AMD than either factor alone (Schmidt et al 2006). This is consistent with reports from family aggregation studies, which suggest that a first-degree relative of an individual with AMD is five times more likely to develop AMD than a family member of som...
متن کاملAssociation of CFI gene polymorphism with age related macular degeneration in Northwest of Iran
Background & Aims: To investigate the association of CFI p.Gly119Arg polymorphism with Age-related macular degeneration (AMD). Materials & Methods: In this case-control study, the association of p.Gly119Arg polymorphism in CFI gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and cont...
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ژورنال
عنوان ژورنال: Ophthalmology
سال: 2008
ISSN: 0161-6420
DOI: 10.1016/j.ophtha.2007.05.038